Top Page | DNA · RNA Synthesis Service | Oligos for Click Chemistry Thesis | Site Map
Oligos for Click Chemistry
forms rigid binding using Huisgen[3+2]cyclization. This reaction is scarcely influenced by environment of reaction system and conditions, and proceeds even in aqueous·biocompatible conditions.
* Click chemistry is coined terms against Huisgen[3+2]cyclization(additional cyclization of alkyne azide)
Outlined Chart of Reaction
We have lined up DNA Oligos which can be used for reaction system of Click Chemistry.
* Please inquire for prices and delivery time.
Azido (-N3) modified DNA Oligos
  It can form binding with alkyne structure.
< 5'Azido structural formula >< 3' Azidostructural formula >
Alkyne (-C≡CH) modified DNA Oligos
  It can form binding with azide structure.
< 5'Alkyne structural formula > < 3'Alkyne structural formula >
It is also possible to undergo internal modification introducing azide in the base part of the sequence or in alkyne.
Reference Literature
Cyclization of Oligonucleotides
Cyclization of Oligonucleotides J.Lietard,A.Meyer,J.J.Vasseur,and F.Morvan, Journal of Organic Chemistry,2008,73,191-200
Conjugation of peptide-DNA
Conjugation of peptide-DNA K.Gogoi,M.V.Mane,S.S Kunte, and V.A.Kumar,Nucleic Acids Res.,2007,35,e139
Immobilization of Oligonucleotides
Immobilization of Oligonucleotides M.V.Kvach, et al.,Nucleosides Nucleotides & Nucleic Acids,2007,26,809-813.D.I.Rozkiewicz, et al., Chembiochem 2007, 8, 1997-2002.
Fluorescent Labeling
Fluorescent Labeling Y.H.Zhang, et al., Tetrahedron, 2007, 63, 6813-6621.
Assembly of DNA on Gold nanoparticles
Assembly of DNA on Gold nanoparticles M.Fischler, et al.,Chem Commun(Camb)2008,169-71